Antinociceptive effect and mechanism of action of isatin, N-methyl isatin and oxopropyl isatin in mice
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چکیده
منابع مشابه
Inhibition of the Corrosion of Mild Steel in Hydrochloric Acid by Isatin and Isatin Glycine
The inhibition of corrosion of mild steel in hydrochloric acid by isatin glycine (ING) and isatin (IN) at 30-60 o C and concentrations of 0.0001 M to 0.0005 M was studied via weight loss method. At the highest inhibitor concentration studied ING exhibited inhibition efficiency of 87% while IN exhibited 84% at 60 o C. A chemical adsorption mechanism was proposed on the basis of the temperature e...
متن کاملAnodic Methoxylation of Isatin
Isatin , w hich is the su b stra te fo r industria l syn thesis o f the m ost p o p u la r fabric dye, the indigo, has been sub ject to elec tro ly tic red u c tio n u n d e r a varie ty of experim en ta l cond itions [1,2]. P o laro graphie b ehav io r o f isatin and a varie ty of isatin derivatives has been described in m any of papers [3 -6 ] , H ow ever, m ost o f those rep o rts w ere d...
متن کاملSimple and efficient microwave assisted N-alkylation of isatin.
We present herein the results of microwave promoted N-alkylations of isatin (1)with different alkyl, benzyl and functionalized alkyl halides. Reactions were carried out under different conditions, always employing methodologies compatible with MW assisted chemistry. Generation of isatin anion employing diverse bases and solvents or using the preformed isatin sodium salt was tested. The best res...
متن کامل5-(Trifluoromethoxy)isatin
THE TITLE COMPOUND [SYSTEMATIC NAME: 5-(trifluoro-meth-oxy)-1H-indole-2,3-dione], C9H4F3NO3, crystallized with two mol-ecules in the asymmetric unit. Inter-molecular N-H⋯O hydrogen bonds link the mol-ecules to form layers parallel to the ab plane. In addition, π-π stacking inter-actions are observed with a centroid-centroid distance of 3.721 (1) Å. The near planarity of the two isatin ring syst...
متن کاملAntipyretic Action of Isatin and Its Analogues in Mice and Rats
The effects of isatin (2,3-dioxo-indole) and isatin analogues (5-methylisatin, 6-hydroxyisatin, 7-ethylisatin, N-acetylisatin) were tested on prostaglandin E2 (PGE2)-induced fever in mice and rats. Two modes of administration were tested. Isatin or an analogue was injected simultaneously with PGE2 and the development of fever was tested, or the test compound was given 30 min following PGE2 admi...
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ژورنال
عنوان ژورنال: Life Sciences
سال: 2016
ISSN: 0024-3205
DOI: 10.1016/j.lfs.2016.02.052